Receptor canabinoide tipo 1

O receptor endocanabinoide tipo 1, muitas vezes abreviado para CB1, é um tipo de receptor canabinoide localizado no cérebro. Ele é ativado por neurotransmissores endocanabinoides incluindo a anandamida, a serotonina e a melatonina,etc... e pelo composto psicoativo"THC", encontrado nas flores da planta da cannabis.

CNR1
Estruturas disponíveis PDB Pesquisa Human UniProt: PDBe RCSB Lista de códigos id do PDB 1LVQ, 1LVR, 2B0Y, 2KOE, 2MZ3, 2MZ2, 2MZA,%%s1LVQ, 1LVR, 2B0Y, 2KOE
Identificadores
Nomes alternativos	CNR1
IDs externos	OMIM: 114610 HomoloGene: 7273 GeneCards: CNR1
Targeted by Drug
HU-210, win 55212-2, Anandamida, canabinol, Tetraidrocanabinol, Org27569, LY-320135, rimonabanto, TM-38837
Ontologia genética Função molecular • G protein-coupled receptor activity • signal transducer activity • cannabinoid receptor activity • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Componente celular • integral component of membrane • intracellular membrane-bounded organelle • membrane • growth cone • integral component of plasma membrane • axónio • membrane raft • membrana plasmática • presynaptic membrane • mitocôndria • mitochondrial outer membrane • cell projection • integral component of mitochondrial membrane • presynapse • glutamatergic synapse • GABA-ergic synapse • integral component of presynaptic membrane Processo biológico • negative regulation of nitric-oxide synthase activity • negative regulation of mast cell activation • glucose homeostasis • response to nutrient • regulation of insulin secretion • negative regulation of blood pressure • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • maternal process involved in female pregnancy • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • response to nicotine • GO:0010260 envelhecimento • positive regulation of fever generation • memória • negative regulation of action potential • regulation of feeding behavior • negative regulation of ion transport • response to morphine • negative regulation of fatty acid beta-oxidation • response to lipopolysaccharide • positive regulation of blood pressure • regulation of penile erection • regulation of lipid metabolic process • espermatogênese • positive regulation of neuron projection development • positive regulation of apoptotic process • positive regulation of acute inflammatory response to antigenic stimulus • learning or memory • nocicepção • negative regulation of dopamine secretion • regulation of synaptic transmission, glutamatergic • response to ethanol • axonal fasciculation • regulation of synaptic transmission, GABAergic • GO:0072468 transdução de sinal • response to cocaine • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission • G protein-coupled receptor signaling pathway • cannabinoid signaling pathway • retrograde trans-synaptic signaling by endocannabinoid • positive regulation of presynaptic cytosolic calcium concentration • induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Padrão de expressão RNA Mais dados de referência de expressão
Ortólogos Espécie Humano Rato Entrez 1268 n/a Ensembl ENSG00000118432 n/a UniProt P21554 n/a RefSeq (mRNA) NM_001160226 NM_001160258 NM_001160259 NM_001160260 NM_016083 NM_033181 NM_001365869 NM_001365870 NM_001365872 NM_001365874 NM_001370545 NM_001370546 NM_001370547 n/a RefSeq (proteína) NP_001153698 NP_001153730 NP_001153731 NP_057167 NP_149421 NP_001352798 NP_001352799 NP_001352801 NP_001352803 NP_001357474 NP_001357475 NP_001357476 n/a Localização (UCSC) n/a n/a Pesquisa PubMed n/a
Wikidata
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Estrutura e Localização

Os receptores CB1 são proteínas acopladas a G (GPCRs) que, quando ativadas, iniciam uma cascata de sinalização intracelular que afeta a neurotransmissão. Eles são codificados pelo gene CNR1 e sua ativação é mediada principalmente pelo ∆9-tetrahidrocanabinol (THC), o principal composto psicoativo encontrado na Cannabis, bem como por endocanabinoides, que são canabinoides produzidos naturalmente pelo corpo, como a anandamida e o 2-aracdonilglicerol (2-AG).